Histology Services
Expert Histology Services for Reliable, High-Quality Results
EPL’s histology labs provide everything from routine tissue processing and staining to advanced dissection and multiplex immunolabeling. Our experienced HT- and HTL-certified histotechnicians work alongside pathologists to recommend preservation, embedding, and sectioning strategies that optimize tissue integrity and target visualization.
Whether your study is standard or specialized, EPL is your trusted partner for customized, high-performance histology services. Contact us to learn how we can support your next project
Aquatic Animal & Avian Histology
Specialized Histology Services for Aquatic and Avian Species
EPL offers expert histologic processing of tissues from aquatic animals and birds, including wild and laboratory species. Our experienced histotechnicians routinely work with fish, amphibians, and avian specimens—delivering high-quality slides with precision and care.With deep experience in regulatory study support, EPL played a key role in the design and validation of original EPA and OECD Tier 1 and Tier 2 assays for endocrine disruption. We are highly proficient in preparing tissues for standardized studies such as the Fish Short-Term Reproduction Assay (FSTRA), Amphibian Metamorphosis Assay (AMA), Medaka Extended One Generation Reproduction Test (MEOGRT), Larval Amphibian Growth and Development Assay (LAGDA), and Avian Two-Generation Toxicity Test in Japanese Quail (JQTT). We can also accommodate assay modifications, alternate species, and additional tissue types.
EPL’s capabilities extend beyond the lab. Our necropsy teams and pathologists are available to travel for on-site dissections in support of environmental investigations. For small specimens such as juvenile frogs or fish, we offer whole-body sectioning techniques that allow evaluation of more than 30 tissues in just two or three slides. We also handle invertebrate samples—including bivalves, crustaceans, and corals—using specialized protocols to ensure specimen integrity and optimal histologic outcomes. At every step, our team ensures that your aquatic and avian samples are processed to the highest scientific standards.
Click here to learn more or to consult with EPL about your aquatic and avian histology needs.
Immunohistochemistry
Advanced Immunohistochemistry Services for Reliable, Reproducible Results
EPL provides expert immunohistochemical (IHC) and immunofluorescent (IF) labeling services to support a wide range of research applications. From routine chromogenic markers to complex multiplex chromogenic and epifluorescent labeling, we develop and optimize protocols for all tissue types, species, and target antigens.Our experienced team works with both paraffin-embedded (FFPE) and frozen specimens, using advanced autostainers including DAKO® and Leica BOND RX systems. These open, programmable platforms allow for automated or manual staining workflows, offering the flexibility and consistency needed for high-throughput studies or highly customized methods. We collaborate closely with clients and antibody vendors, tailoring each protocol with techniques such as serial antibody dilutions, antigen retrieval, and detailed troubleshooting. All optimization procedures are fully documented under EPL SOPs and performed according to Good Laboratory Practice (GLP) standards. EPL routinely optimizes antibody performance per study, antibody vendor, and lot, ensuring reliable, reproducible data for every project. We have optimized protocols for a number of antibodies, with some examples listed below:
Key Points
- Actin
- Alpha-synuclein
- ß-Catenin
- BrdU
- CAR
- CD4
- CD8 (OX-8)
- Complement C3
- COX-2
- Cyclin D1
- Cytokeratin (WSS)
- Desmin
- F4/80
- Factor VIII
- Gamma-H2AX
Click here to learn more about our IHC and IF capabilities, or to speak with a pathologist about your specific study needs.
Necropsy
Flexible, On-Site Preclinical Necropsy Services.
EPL offers professional necropsy services performed by experienced staff, with meticulous tissue collection and the flexibility to operate on-site at your facility. Our trained prosectors work seamlessly with your team to ensure high-quality, consistent results across all laboratory species.All necropsy procedures can be supervised by one of EPL’s board-certified veterinary pathologists, providing scientific oversight and ensuring regulatory compliance throughout the process.
Let EPL support your next study with reliable, expert necropsy services—delivered where and when you need them.
Routine H&E
At EPL, routine histology is anything but routine.
We provide expert tissue processing and hematoxylin and eosin (H&E) staining, delivering high-quality glass slides that reflect both scientific accuracy and technical artistry. Our histotechnicians are skilled in working with tissues from nearly all laboratory species, ensuring consistency and clarity across your studies.
Whether you’re conducting a small pilot study or a large-scale project, EPL has the capacity and experience to meet your timelines without compromising quality. Partner with us to streamline your histology workflow and enhance your next study.
Ask us more about our H&E Histology
Specialty Histochemical Stains
Expert Special Stains to Support Complex Research Needs
EPL offers an extensive menu of special stains and advanced staining techniques to help you visualize tissue structure, cell types, and pathology with clarity and precision. From routine histochemical stains to highly specialized or novel methods, our team is ready to elevate the quality and impact of your research.We routinely perform stains such as the Periodic acid-Schiff (PAS) reaction, as well as complex procedures like Bielschowsky silver stain and the modified Russell-Movat pentachrome stain. Our experienced histotechnicians take pride in mastering challenging or uncommon stains—and we welcome the opportunity to develop custom techniques tailored to your study objectives.
Contact EPL to discuss your special staining requirements and how we can support your next project with expert histologic detail.