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  • Biological Testing
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  • Toxicology

Blind Slide Reading

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In toxicologic pathology, “blind slide reading” involves procedures in which the pathologist is unaware of the treatment group status of individual animals during the histologic slide evaluation phase of a toxicologic bioassay.  Blind slide reading continues to be a controversial topic, despite published recommendations on this subject authored by professional societies and governmental regulatory agencies […]

Using Transmission Electron Microscopy in Preclinical Safety Studies

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The use of Transmission Electron Microscopy (TEM) in preclinical studies has significantly waned in the last 20 or so years.  There are multiple reasons for this.  TEM is expensive and labor intensive.  Compared to standard histopathology, TEM requires significantly more time and money to analyze samples.  The cost of maintaining an electron microscope is practical […]

Histology Slide Quality

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A quality histological slide contains tissue that was properly sampled, fixed, processed, embedded, microtomed, and stained without artifacts. The production of a quality slide requires work be conducted according to the highest standards during each phase of histologic processing. The first and most important steps are precise necropsy techniques (e.g., postmortem interval, tissue sample size […]

On-Time Pathology Reporting

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It is every client’s desire and expectation that their study report will be completed “On-Time” or better yet, be available ahead of schedule. There are a number of factors that determine whether a pathology report will be early, on time, or in the worst case scenario, delayed. Most situations are readily managed, but in rare […]

EXPEDITED SCHEDULING OF HISTOLOGY AND HISTOPATHOLOGY

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Kerry Crabb, HTL(ASCP), is the Manager of North Carolina Laboratory Operations at EPL. Kerry joined EPL in 2015, and brought with him over 25 years of experience in managing histology laboratories. Kerry’s experience at both large pharmaceutical and agrochemical companies gave him a broad knowledge on some of the best practices related to histology and […]

Immunohistochemical Assay Optimization – Tackling Intrinsic Study Variables

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Immunohistochemistry (IHC) is employed routinely for investigative and diagnostic evaluations of antigen-antibody interactions within cells or tissues. While most IHC target antigens are proteins, other antigenic biological substrates can also be recognized by antibodies (e.g., carbohydrates, lipids, or nucleic acids). Accurate and reproducible results are achieved when procedures used to identify and localize tissue antigens […]

EPL Histology – Tissue Accountability and Routine Recut Procedures

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Since 1971, EPL has developed and refined methods to provide high quality and efficient histopathology services. The following information details some of the steps taken during histology processing and preparation at EPL, to ensure tissue accountability and define routine tissue recut procedures. Tissue Accountability on All Studies: Each study received at EPL will be assigned […]

Information List for EPL’s Unique Pathology Peer Review System

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In 2017, EPL has conducted 189 pathology peer reviews, including 28 peer reviews on 2-year carcinogenicity studies and transgenic rasH2 mouse 26-week carcinogenicity projects.  Each project requires set up of our unique peer review system ahead of the actual peer review conduct. Our PQA software program is a computerized pathology peer review procedure developed at […]

Histology – How to Ensure the Quickest Possible Timeline

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With the processing of up to 50,000 tissues per month, and projects regularly flowing in and out of our labs, histology scheduling at EPL is a continual process. Recognizing that the project timeline, in addition to quality and expertise, is one of the most important factors to our clients, we’re providing the following tips on […]

EPL Pathology Peer Review

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When selecting a Pathology Peer Review provider, experience is an important factor to consider in order to ensure high quality pathology data.  Over the last two years alone, EPL has conducted more than 250 pathology peer reviews.  These pathology peer reviews have been conducted internationally, with reviews being performed across North America, Asia, and Europe.  […]

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