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Histology Slide Quality
A quality histological slide contains tissue that was properly sampled, fixed, processed, embedded, microtomed, and stained without artifacts. The production of a quality slide requires that work be conducted according to the highest standards during each phase of histologic processing. The first and most important steps are precise necropsy techniques (e.g., postmortem interval, tissue sample […]
Drug-induced Vascular Injury (DIVI): An Often Complicated Issue
Drug-induced vascular injury (DIVI) is a major concern for development of new and novel therapies. Efforts to identify biomarkers consistent with DIVI have not been successful, largely attributed to the complex nature of the vascular responses to injury and a lack of understanding of the mechanisms controlling these responses. Recent publications on biomarkers of DIVI […]
EPL Clinical Pathology Evaluation and Consultation Services
Experimental Pathology Laboratories, Inc. (EPL) is pleased to announce that Dr. Valerie Barlow will be providing clinical pathology evaluation and consultation services for EPL. Dr. Valerie G. Barlow holds a DVM, a Master of Science and Ph.D., and is a Diplomate of the American College of Veterinary Pathologists (clinical pathology). Dr. Barlow was born and […]
The Benefits of Immunohistochemistry (IHC)
Immunohistochemistry (IHC) has become a routinely used methodology for investigative and diagnostic evaluations that utilizes antigen-antibody reactions to identify antigens within cells or tissues. While antigens are usually proteins, other antigenic biological products can also be recognized by antibodies including carbohydrates, lipids, nucleic acids, and others. The identification and localization of tissue antigens using IHC […]
EPL, Inc. Opens a Midwest Office in West Lafayette, Indiana
Experimental Pathology Laboratories, Inc. (EPL) opened a Midwest facility on September 1, 2014. This office is headed by Dr. Paul Snyder formerly a Professor at Purdue University. The Midwest office is located in the Purdue Research Park at 1305 Cumberland Ave., West Lafayette, IN. With this central location, Dr. Snyder will be able to provide local […]
EPL Announces New Alliance for Electron Microscopy Services
EPL is pleased to announce that electron microscopy services will be provided in conjunction with the Laboratory for Neurotoxicity Studies (LNS) at the Virginia-Maryland College of Veterinary Medicine at Virginia Tech in Blacksburg, VA. Operating under the Virginia-Maryland College of Veterinary Medicine GLP Program, the LNS is a fully GLP-compliant, state-of-the-art transmission electron microscopy laboratory that […]
Evolving Roles of the Toxicologic Pathologist in Multi-disciplinary Research
The role of the toxicologic pathologist is continuously evolving and becoming ever more complex, as novel tools are being developed to identify structural and biochemical changes that result from exposure to toxic substances, and elucidate mechanisms of action by which toxins may potentially impact animal and human health. Recently, EPL has been working with ToxStrategies […]
Ocular Toxicity Studies: Specialized Necropsy, Histology, and Pathology Methods
The eye and the ocular adnexa are common target organs in toxicology studies, but the appropriate evaluation of ocular tissues is a specialized endeavor. Compared to routine toxicity studies, ocular toxicity studies require methodological modifications at almost every stage from study design to the final pathology report. For example, at necropsy, the fragile nature of […]
Approaches to Design-Based Stereology
In contrast to two-dimensional image analysis, the goal of modern design-based stereology is to provide an unbiased estimate of the absolute number or size of measured objects within a three-dimensional region of interest, as opposed to a relative value (e.g., number of objects per unit area, i.e., density). This approach allows valid comparisons to be […]
Pathology Working Groups (PWG) Conducted by EPL
A Pathology Working Group (PWG) is a specialized type of review composed of a group of expert pathologists convened to answer specific questions and provide an independent unbiased opinion regarding study results. They may be convened by study sponsors, consortiums, or government agencies. Members of the PWG may come from academia, government, or industry and […]