Category: Pathology

Blind Slide Reading

In toxicologic pathology, “blind slide reading” involves procedures in which the pathologist is unaware of the treatment group status of individual animals during the histologic slide evaluation phase of a toxicologic bioassay.  Blind slide reading continues to be a controversial topic, despite published recommendations on this subject authored by professional societies and governmental regulatory agencies […]

PathologySafety AssessmentToxicology

EPL’s Whole Slide Imaging Services

EPL’s experience with and use of whole slide images dates to the early 2000s. Our digital imaging technicians are dedicated to capturing your slides as the best digital surrogates to meet your consultation, educational, digital peer review, or quantitative analysis* needs. Our VA and NC locations provide high-throughput whole slide imaging services to our clients […]

HistologyLaboratory SciencePathology

Stereology: Probing for Precision

Stereology is a tool for obtaining unbiased estimates of object numbers and/or sizes within three-dimensional regions of interest.  For biological samples, quantitative measurements are potentially more objective and accurate when compared to traditional semi-quantitative grading of findings by pathologists (i.e., scoring of morphologic changes as minimal, mild, moderate, or severe).  Although both approaches require high […]


Immunostaining Assay Optimization – Tackling Intrinsic Study Variables

Immunohistochemistry or Immunofluorescence (IHC/IF) is employed routinely for investigative and diagnostic evaluations of antigen-antibody interactions within cells or tissues. While most IHC/IF target antigens are proteins, other antigenic biological substrates can also be recognized by antibodies (e.g., carbohydrates, lipids, or nucleic acids). Accurate and reproducible results are achieved when procedures used to identify and localize […]

DiscoveryHistologyPathologySafety AssessmentToxicology

Pathology Peer Review

Experimental Pathology Laboratories, Inc. (EPL) meets or exceeds current FDA guidelines following the release of “Pathology Peer Review in Nonclinical Studies: Questions and Answers, Guidance for Industry” document in December 2021

Laboratory SciencePathologyToxicology

Experimental Pathology Laboratories, Inc. Announces a Strategic Alliance with Quality Scientific Solutions, LLC

Experimental Pathology Laboratories, Inc. (EPL) announces a new strategic alliance with Quality Scientific Solutions, LLC (QS3). This alliance is targeted to provide EPL’s preclinical pathology expertise as an important resource to QS3. About Quality Scientific SolutionsQuality Scientific Solutions, LLC is a research and consulting company dedicated to helping clients create products that meet the highest standard […]


EPL – Independent and Employee-Owned

Experimental Pathology Laboratories, Inc. (EPL) is an independent, private, employee-owned company that is recognized internationally for its ability to meet the needs of the scientific community and the challenges of preclinical safety testing and development with high quality histopathology services.  EPL was founded in 1971, and became an employee-owned company in 1992.  EPL is proud […]

DiscoveryHistologyPathologySafety AssessmentToxicology

Aclairo Welcomes Dr. Heath Thomas as New President

Experimental Pathology Laboratories, Inc. (EPL) and Aclairo Pharmaceutical Development Group, Inc. (Aclairo) are excited to announce that Dr. Heath Thomas has joined Aclairo as President and Senior Consultant. Dr. Thomas is a board-certified veterinary pathologist with over 20 years of experience in drug development from time spent with SmithKline Beecham, DuPont Pharmaceuticals, and GlaxoSmithKline, as […]

Biological TestingClinical Pharmacology & ModelingDiscoveryPathologySafety AssessmentToxicology

Using Transmission Electron Microscopy in Preclinical Safety Studies

The use of Transmission Electron Microscopy (TEM) in preclinical studies has significantly waned in the last 20 or so years.  There are multiple reasons for this.  TEM is expensive and labor intensive.  Compared to standard histopathology, TEM requires significantly more time and money to analyze samples.  The cost of maintaining an electron microscope is practical […]

HistologyPathologySafety AssessmentToxicology

On-Time Pathology Reporting

It is every client’s desire and expectation that their study report will be completed “On-Time” or better yet, be available ahead of schedule. There are a number of factors that determine whether a pathology report will be early, on time, or in the worst case scenario, delayed. Most situations are readily managed, but in rare […]

HistologyPathologySafety AssessmentToxicology