Category: Histology

How to Ensure the Quickest Possible Histology Project Timeline

With the processing of up to 50,000 tissues per month, and projects regularly flowing in and out of our labs, histology scheduling at EPL is a continual process. Recognizing that the project timeline, in addition to quality and expertise, is one of the most important factors to our clients, we’re providing the following tips on the items […]

Histology

EPL – Independent and Employee-Owned

Experimental Pathology Laboratories, Inc. (EPL) is an independent, private, employee-owned company that is recognized internationally for its ability to meet the needs of the scientific community and the challenges of preclinical safety testing and development with high quality histopathology services.  EPL was founded in 1971, and became an employee-owned company in 1992.  EPL is proud […]

DiscoveryHistologyPathologySafety AssessmentToxicology

Using Transmission Electron Microscopy in Preclinical Safety Studies

The use of Transmission Electron Microscopy (TEM) in preclinical studies has significantly waned in the last 20 or so years.  There are multiple reasons for this.  TEM is expensive and labor intensive.  Compared to standard histopathology, TEM requires significantly more time and money to analyze samples.  The cost of maintaining an electron microscope is practical […]

HistologyPathologySafety AssessmentToxicology

Histology Slide Quality

A quality histological slide contains tissue that was properly sampled, fixed, processed, embedded, microtomed, and stained without artifacts. The production of a quality slide requires work be conducted according to the highest standards during each phase of histologic processing. The first and most important steps are precise necropsy techniques (e.g., postmortem interval, tissue sample size […]

Histology

On-Time Pathology Reporting

It is every client’s desire and expectation that their study report will be completed “On-Time” or better yet, be available ahead of schedule. There are a number of factors that determine whether a pathology report will be early, on time, or in the worst case scenario, delayed. Most situations are readily managed, but in rare […]

HistologyPathologySafety AssessmentToxicology

EXPEDITED SCHEDULING OF HISTOLOGY AND HISTOPATHOLOGY

Kerry Crabb, HTL(ASCP), is the Manager of North Carolina Laboratory Operations at EPL. Kerry joined EPL in 2015, and brought with him over 25 years of experience in managing histology laboratories. Kerry’s experience at both large pharmaceutical and agrochemical companies gave him a broad knowledge on some of the best practices related to histology and […]

HistologyPathologySafety AssessmentToxicology

Immunohistochemical Assay Optimization – Tackling Intrinsic Study Variables

Immunohistochemistry (IHC) is employed routinely for investigative and diagnostic evaluations of antigen-antibody interactions within cells or tissues. While most IHC target antigens are proteins, other antigenic biological substrates can also be recognized by antibodies (e.g., carbohydrates, lipids, or nucleic acids). Accurate and reproducible results are achieved when procedures used to identify and localize tissue antigens […]

DiscoveryHistologyPathologySafety AssessmentToxicology

EPL Histology – Tissue Accountability and Routine Recut Procedures

Since 1971, EPL has developed and refined methods to provide high quality and efficient histopathology services. The following information details some of the steps taken during histology processing and preparation at EPL, to ensure tissue accountability and define routine tissue recut procedures. Tissue Accountability on All Studies: Each study received at EPL will be assigned […]

HistologyPathology

Histology – How to Ensure the Quickest Possible Timeline

With the processing of up to 50,000 tissues per month, and projects regularly flowing in and out of our labs, histology scheduling at EPL is a continual process. Recognizing that the project timeline, in addition to quality and expertise, is one of the most important factors to our clients, we’re providing the following tips on […]

HistologyPathology

A Closer Look at Ocular Toxicity Studies

The eye and the ocular adnexa are common target organs in toxicology studies, but the appropriate evaluation of ocular tissues is a specialized endeavor.   Compared to routine toxicity studies, ocular toxicity studies require methodological modifications at almost every stage from study design to the final pathology report. EPL has extensive experience in the processing and […]

HistologyPathologySafety AssessmentToxicology